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High levels of hormones do not always indicate cheating, and low levels do not always guarantee innocence. For example, Finnish cross-country skiing champion Eero Mantyranta, who won two gold medals in the 1964 Winter Olympics, had a genetic mutation which enabled him to produce unusually high levels of erythropoietin (EPO). How can we set fair benchmarks that catch the cheats but don’t return false positives on athletes operating by the rules? One solution introduced in 2009 is statistical profiling, which essentially allows testers to create a ‘biological passport’ for each athlete. Athlete Biological Passports (ABPs) are a unique, personalised electronic record of an athlete’s biological values, developed over time from multiple collections of blood samples. The ABP collates data on the levels of different substances in the body, during and after exercise, and uses this to construct a profile, effectively determining natural levels of various substances in the body for each individual. From this information, testers can assess if an athlete suddenly has a large jump in certain hormones or proteins in their blood, when compared against their normal levels. This could indicate that doping has occurred. An athlete biological passport showing a negative reading for steroid use. Image source: World Anti-doping Authority. An athlete biological passport showing a positive reading for steroid use. Image source: World Anti-doping Authority. The initial ABPs contained a standardised approach to the profiling of an athlete’s haematological variables (blood module) for the detection of blood doping. Since 2014 ABPs also include a steroidal module, which monitors selected urinary steroid concentrations over time to monitor for potential steroid doping. The Australian Sports Anti-Doping Authority (ASADA) notes that ‘ The ABP differs from traditional detection methods by looking for the effects of blood doping rather than detecting the prohibited substances or methods used. The advantage of this approach is the biological effects of a performance-enhancing agent are commonly present and detectable for a longer period than the agent itself, buy ultima proviron 25 mg oral steroids $42.00 proviron. Long term effects of doping. Most athletes dope for short-term gain, but what are the long-term implications of using these drugs? From a health perspective, the verdict is unclear. As listed above, all doping drugs have potential immediate or short-term side-effects and drawbacks, but scientists are still researching the longer-term effects they may have on the body. Some studies have found evidence of early mortality due to cancer or heart attack amongst previous long-term users of PEDs, but these are inconclusive as other factors such as lifestyle, and genetics may also be responsible. Part of the difficulty is in finding athletes who would agree to participate in such a study. From a performance point of view, scientists from the University of Oslo have released preliminary findings showing that athletes may continue to benefit from having taken banned substances long after the drugs have left their system and their bans have been lifted. The 2013 study, which was undertaken on mice, found that muscles can retain some of the advantages gained through anabolic steroid use for years, possibly even decades after the drugs were taken. Kristian Gunderson, Professor of Physiology at the University of Oslo said ‘If you exercise, or take anabolic steroids, you get more nuclei and you get bigger muscles. undefined