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The data does seem to show that infusions of these hormones promote protein breakdown in most tissues throughout the body and stimulates the oxidation of amino acids. They may also impair protein synthesis after chronic exposure and blunt the release of insulin and paracrine IGF-1. Ultimately the summation of these actions results in a net catabolic effect. However, don’t misconstrue this message to mean that acute bursts of these hormones (as seen during times of acute stress) are counterproductive to muscle growth since that is missing the bigger picture; again, stress hormones are a necessary part of human physiology, . Unless you have abnormally high cortisol, glucagon, and epinephrine concentrations in the blood for prolonged periods of time (e.